Technical University of Munich
Professur für Pharmazeutische Radiochemie (Prof. Tredwell)
Walther-Meißner-Str. 3
85748 Garching b. München
Professor Tredwell studied Chemistry at the University Oxford, where he earned his doctorate in organic chemistry in 2007 before completing postdoctoral research at both the University of Cambridge and the University of Oxford. He established his independent research group at the Max-Planck-Institute für Kohlenforschung in 2015. In 2019, Professor Tredwell joined Cardiff University, appointed jointly between the Schools of Chemistry and Medicine. Since 2026, he is Professor of Pharmaceutical Radiochemistry at TUM.
Prof. Tredwell’s (*1981) research spans the fields of chemical synthesis, radiochemistry, and the development of targeted radiopharmaceuticals for imaging and therapy. He has developed innovative methods and reagents for the 18F-fluorination of small molecules and biomolecules, enabling the efficient production of positron emission tomography (PET) radiotracers, particularly for neuroimaging. These methods have been widely adopted for both research and clinical studies.
Angewandte Chemie - International Edition
Abstract: The development of 18F-labelled radiotracers is of vital importance for (pre)clinical positron emission tomography (PET) imaging and to guide drug discovery campaigns. State-of-the-art approaches…
Journal of the American Chemical Society
Abstract: Herein, we report a Ni-mediated 18F,D2-monofluoromethylation of (hetero)arenes from (pseudo)halide coupling partners. This new approach offers key advantages compared to traditional radiochemistry…
Journal of Experimental Botany
Abstract: Mycorrhizal fungi form essential symbiotic relationships with plant roots, facilitating nutrient exchange and promoting plant health. Understanding their interactions can benefit from advanced imaging…
Organic Letters
Abstract: The synthesis of functionalized cubanols has been developed via a 2-step protocol comprising of a Baeyer–Villiger oxidation of cubyl ketones, followed by acid hydrolysis. As part of this study, we…
Organic Letters
Abstract: (Hetero)aryl pinacol boronic esters are routinely used for 18F-labeling and have accelerated numerous diagnostic and drug discovery programs. An analysis of the current state-of-play, however,…
Organic Letters
Abstract: 18F radiotracers are used in positron emission tomography imaging for medical diagnosis and drug development. Current methods to synthesize 18F-polyfluorinated functional groups are limited in…
Chemical Communications
Abstract: Enantioenriched [18F]SynVesT-1 and [18F]SynVesT-2 are prepared from the corresponding enantioenriched arylboronic esters and [18F]fluoride mediated by (Py)4Cu(OTf)2. The 18F-reaction is optimised on…
Journal of the American Chemical Society
Abstract: Herein, we report a photoredox nucleophilic (radio)fluorination using TEMPO-derived alkoxyamines, a class of substrates accessible in a single step from a diversity of readily available carboxylic…
Angewandte Chemie - International Edition
Abstract: Herein, we disclose that pyridinium salts derived from abundant (hetero)anilines represent a novel precursor class for nucleophilic aromatic substitution reactions with [18F]fluoride. The value of…
Organic Letters
Abstract: Herein, we report that α-fluorocarboxylic acids undergo manganese-mediated oxidative 18F-fluorodecarboxylation with [18F]-fluoride affording biologically relevant 18F-difluoromethyl(ene)-containing…
