Klemens M. Thaler1 , Lorenza Gilardi1 , Markus Weber1 , Andreas Vohburger1 , Zisimos Toumasatos2 , Anastasios Kontses2 , Zissis Samaras2 , Joni Kalliokoski3 , Pauli Simonen3 , Hilkka Timonen4 , Minna Aurela4 , Sanna Saarikoski4 , Sampsa Martikainen3 , Panu Karjalainen3 , Miikka Dal Maso3 , Jorma Keskinen3 , Reinhard Niessner1 , Genny A. Pang1 , Christoph Haisch
HELIOS/SICRIT/Mass Spectrometry for Analysis of Aerosols in Engine Exhaus. Aerosol Science and Technology (2021)

Markus Weber, Jan Christoph Wolf, Christoph Haisch
Gas chromatography - atmospheric pressure inlet - mass spectrometer utilizing plasma-based soft ionization for the analysis of saturated, aliphatic hydrocarbons. Journal of the American Society for Mass Spectrometry (2021)

Zhou X, Hu ZW, Yang DT, Xie SX, Jiang ZJ, Niessner R, Haisch C, Zhou HB, Sun PH (2020) Bacteria detection: From powerful SERS to its advanced compatible techniques. Advanced Science. doi:ARTN 200173910.1002/advs.202001739

Samaras ZC, Andersson J, Bergmann A, Hausberger S, Toumasatos Z, Keskinen J, Haisch C, Kontses A, Ntziachristos LD, Landl L, Mamakos A, Bainschab M (2020) Measuring automotive exhaust particles down to 10 nm. SAE Technical Paper.

Deiringer N, Haase C, Zahler S, Haisch C, Friess W (2020) Finding the needle in the haystack: High-resolution techniques for characterization of mixed protein particles containing shed silicone rubber particles generated during pumping. Journal of Pharmaceutical Sciences.

Hagen FP, Rinkenburger A, Gunther J, Bockhorn H, Niessner R, Suntz R, Loukou A, Trimis D, Haisch C (2020) Spark discharge-generated soot: Varying nanostructure and reactivity against oxidation with molecular oxygen by synthesis conditions. Journal of Aerosol Science 143 doi:ARTN 105530 10.1016/j.jaerosci.2020.105530

Pang GA, Bauer M, Haisch C (2020) Aerosol generation from laser-ablation-synthesized nanoparticles. Synthesis and Photonics of Nanoscale Materials Xvii 11269. doi:Artn 112690g10.1117/12.2543021

Pang GA, Haisch C, Laufer J (2020) Quenching of nonlinear photoacoustic signal generation in gold nanoparticles through coating. Nanoscale Advances. doi: 10.1039/D0NA00205D, selected as HOT ARTICLE

Schädler T, Neumann-Cip A-C, Wieland K, Glöckler D, Haisch C, Brück T, Weuster-Botz D (2020) High-density microalgae cultivation in open thin-layer cascade photobioreactors with water recycling. Applied Sciences 10 (11): 3883. doi: 10.3390/app10113883

Bauer D, Wieland K, Qiu L, Neumann-Cip AC, Magistro G, Stief C, Wieser A, Haisch C (2020) Heteroresistant bacteria detected by an extended Raman-based antibiotic susceptibility test. Anal Chem 92 (13):8722-8731. doi:10.1021/acs.analchem.9b05387

Lumpe H, Menke A, Haisch C, Mayer P, Kabelitz A, Yusenko KV, Buzanich AG, Block T, Pöttgen R, Emmerling F, Daumann L The earlier the better: Structural analysis and separation of lanthanides with pyrroloquinoline quinone. Chemistry – A European Journal n/a (n/a). doi:10.1002/chem.202002653

Qiu L, Pang GA, Zheng G, Bauer D, Wieland K, Haisch C (2020) Kinetic and mechanistic investigation of the photocatalyzed surface reduction of 4-nitrothiophenol observed on a silver plasmonic film via surface-enhanced Raman scattering. ACS Applied Materials & Interfaces. doi:10.1021/acsami.0c05977

Ploetz E, Zimpel A, Cauda V, Bauer D, Lamb DC, Haisch C, Zahler S, Vollmar AM, Wuttke S, Engelke H (2020) Metal-organic framework nanoparticles induce pyroptosis in cells controlled by the extracellular ph. Adv Mater n/a (n/a):e1907267. doi:10.1002/adma.201907267

Bauer D, Qiu L, Wieland K, Neumann-Cip AC, Wieser A, Magistro G, Stief C, Haisch C (2020) Deuterium uptake in combination with Raman spectroscopy as a tool to investigate antibiotic susceptibility of bacteria. Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020 11223. doi:Artn 112230210.1117/12.2553093


Pang, G. A., Qiu, L., Haisch, C., & Laufer, J. (2019). Towards biochemical sensing with gold nanoparticles through suppression of nonlinear photoacoustic signal generation. Photons Plus Ultrasound: Imaging and Sensing 2019, 10878. doi: Artn 108786q 10.1117/12.2523417

Pintus, V., Baragona, A. J., Wieland, K., Schilling, M., Miklin-Kniefacz, S., Haisch, C., & Schreiner, M. (2019). Comprehensive Multi-Analytical Investigations on the Vietnamese lacquered Wall-Panel “The Return of the Hunters” by Jean Dunand. Scientific Reports, 9(1), 18837. doi: 10.1038/s41598-019-55471-6

Rinkenburger, A.;  Niessner, R.; Haisch, C., On-line determination of soot oxidation reactivity. J. Aerosol Sci. (2019), 132, 12-21, DOI: 10.1016/j.jaerosci.2019.03.002

Neumann, A. C.; Bauer, D.; Hoelscher, M.; Haisch, C.; Wieser, A., Identifying Dormant Growth State of Mycobacteria by Orthogonal Analytical Approaches on a Single Cell and Ensemble Basis. Anal. Chem. (2019), 91, 881-887, DOI: 10.1021/acs.analchem.8b03646

Gherman, A. M. R.;  Dina, N. E.;  Chis, V.;  Wieser, A.; Haisch, C., Yeast cell wall - Silver nanoparticles interaction: A synergistic approach between surface-enhanced Raman scattering and computational spectroscopy tools. Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy (2019), 222, DOI: 10.1016/j.saa.2019.117223


Yuan, K.; Mei, Q.; Guo, X.; Xu, Y.; Yang, D.; Sánchez, B. J.; Sheng, B.; Liu, C.; Hu, Z.; Yu, G.; Ma, H.; Gao, H.; Haisch, C.; Niessner, R.; Jiang, Z.; Zhou, H., Antimicrobial peptide based magnetic recognition elements and Au@Ag-GO SERS tags with stable internal standards: a three in one biosensor for isolation, discrimination and killing of multiple bacteria in whole blood. Chemical Science 2018, DOI: 10.1039/C8SC04637A.

Yang, D. T.; Zhou, H. B.; Dina, N. E.; Haisch, C., Portable bacteria-capturing chip for direct surface-enhanced Raman scattering identification of urinary tract infection pathogens. Royal Society Open Science 2018, 5 (9).

Thaler, K. M., Schwartz, A. J., Haisch, C., Niessner, R., Hieftje, G. M. Preliminary survey of matrix effects in the microwave-sustained, inductively coupled atmospheric-pressure plasma (MICAP).  Talanta (2018) 180, 25-31.

Dina, N. E.;  Gherman, A. M. R.;  Chis, V.;  Sarbu, C.;  Wieser, A.;  Bauer, D.; Haisch, C., Characterization of Clinically Relevant Fungi via SERS Fingerprinting Assisted by Novel Chemometric Models. Anal. Chem. (2018), 90,


Thaler, K. M., Niessner, R., Haisch, C. Laboratory and field studies on a new sensor for dissolved N2O. Anal Bioanal Chem (2017) 409, 4719-4727.

Thaler, K. M., Berger, C., Leix, C., Drewes, J., Niessner, R., Haisch, C. Photoacoustic spectroscopy for the quantification of N2O in the off-gas of wastewater treatment plants. Anal Chem (2017) 89,

Dina, N. E., Zhou, H., Colnita, A., Leopold, N., Szoke-Nagy, T., Coman, C., Haisch, C. Rapid single-cell detection and identification of pathogens by using surface-enhanced Raman spectroscopy. Analyst (2017) 142, 1782-1789.


Cremer, J.; Thaler, K.; Haisch, C.; Signorell, R. Photoacoustics of single laser-trapped nanodroplets for the direct observation of nanofocusing in aerosol photokinetics. Nature Communications (2016) 10941.

Zhou, H., Wang, Q., Yuan, D., Wang, J., Yang, H., Wu, H., Jian, J., Yang, D., Huang, N., Haisch, C, Jiang, Z., Chen, S. Early apoptosis real-time detection by label-free SERS based on externalized phosphatidylserine. Analyst (2016) 141, 4293-4298.

Pang, G. A., Laufer, J., Niessner, R, Haisch, C. Photoacoustic signal generation in gold nanospheres in aqueous solution: Signal generation enhancement and particle diameter effects. The Journal of Physical Chemistry C (2016) 120,

Liu, L. X., Mandelis, A., Melnikov, A., Michaelian, K., Huan, H. T., Haisch, C. Step-scan T-cell fourier transform infrared photoacoustic spectroscopy (FTIR-PAS) for monitoring environmental air pollutants. Int J Thermophys. (2016) 37 (7)

Haisch, C. Raman-based microarray readout: A review. Anal Bioanal Chem (2016) 408,

El Bali B., Lachkar M., Essehli R., Dusek M., Rohlicek J., Mircescu N., Haisch, C. NaCo(H2PO2)3: Crystal structure and physical study. Journal of Molecular Structure (2016) 1123,

Yang, D.; Zhou, H.; Haisch, C.; Niessner, R.; Ying, Y., Reproducible E. coli detection based on label-free SERS and mapping. Talanta (2016) 457-463.


Zhou, H. B.; Yang, D. T.; Mircescu, N.; Ivleva, N.; Schwarzmeier, K.; Wieser, A.; Schubert, S.; Niessner, R.; Haisch, C., Surface-enhanced Raman scattering detection of bacteria on microarrays at single cell levels using silver nanoparticles. Microchim. Acta (2015) 2259-2266.

Zhou, H. B.; Yang, D. T.; Ivleva, N. P.; Mircescu, N. E.; Schubert, S.; Niessner, R.; Wieser, A.; Haisch, C., Label-Free in Situ Discrimination of Live and Dead Bacteria by Surface-Enhanced Raman Scattering. Anal. Chem. (2015) 6553-6561.

Menzen, T.; Friess, W.; Niessner, R.; Haisch, C., Laser-induced breakdown detection of temperature-ramp generated aggregates of therapeutic monoclonal antibody. European Journal of Pharmaceutics and Biopharmaceutics (2015) 463-467.

Liu, X., Tang, L., Niessner, R., Ying, Y., Haisch, C. Nitrite-triggered surface plasmon-assisted catalytic conversion of p-aminothiophenol to p,p’-dimercaptozaobenzene on gold nanoparticle: SERS investigation and potential for NO2-detection. Anal. Chem. (2015) 499-506.


Mircescu, N. E., Zhou, H., Leopold, N., Chis, V., Ivleva, N. P., Niessner, R., Wieser, A., Haisch, C. Towards a receptor-free immobilization and SERS detection of urinary tract infections causative pathogens. Anal. Bioanal. Chem. (2014) 3051–3058.

Wolf, J.-C., Danner, A., Nießner, R., Haisch, C. NO2 measurement artifacts in the presence of soot. Analytical and Bioanalytical Chemistry (2013) 447-453. DOI 10.1007/s00216-013-7495-8.

Zhou, H. B., Yang, D. T., Ivleva, N. P., Mircescu, N. E., Niessner, R., Haisch, C., SERS detection of bacteria in water by in situ coating with Ag nanoparticles. Anal. Chem. (2014) 1525-1533.

"As of July/August 2019, this highly cited paper received enough citations to place it in the top 1% of the academic field of Chemistry based on a highly cited threshold for the field and publication year."


Yang D., Mircescu N. E., Zhou, H., Leopold N., Chis, V., Oltean, M., Ying, Y. Haisch, C. DFT study and quantitative detection by surface-enhanced Raman scattering (SERS) of ethyl carbamat. Journal of Raman Spectroscopy (2013) 1491-1496.

Yang T. D., Zhou, B. H, Ying, B. Y., Niessner, R., Haisch, C.  Surface-enhanced Raman scattering for quantitative detection of ethyl carbamate in alcoholic beverages. Analytical and Bioanalytical Chemistry (2013) 9419-9425.

Ivleva N., Huckele, S., Weinzierl, B., Niessner, R., Haisch, C., Baumann, T. Identification and characterization of individual airborne volcanic ash particles by Raman microspectroscopy. Analytical and Bioanalytical Chemistry (2013) 9071-9084.

Schwarzmeier, K., Knauer, M., Ivleva, P. N., Niessner, R., Haisch, C. Bioaerosol analysis based on a label-free microarray readout method using surface-enhanced Raman scattering. Analytical and Bioanalytical Chemistry (2013) 5387-5392.


Haisch, C., Niessner, R., A Photoacoustic analyzer for the artifact-free parallel detection of soot and NO2 in engine exhaust. Analytical Chemistry (2012) 7292–7296.

Wurth, C., Gonzalez, G. M., Niessner, R., Panne, U., Haisch, C., Resch-Genger, U., Determination of the absolute fluorescence quantum yield of rhodamine 6g with optical and photoacoustic methods - providing the basis for fluorescence quantum yield standards. Talanta (2012).

Haisch; C., Menzenbach, P., Bladt; H., Niessner, R., A wide spectral range photoacoustic aerosol absorption spectrometer. Analytical Chemistry (2012).

Haisch, C. Optical tomography. Annual Review of Analytical Chemistry (2012).

Knauer, M., Ivleva, P. N., Niessner, R., Haisch, C. A flow-through microarray cell for the online SERS analysis of antibody-captured E. coli bacteria, Analytical and Bioanalytical Chemistry (2012) 2663-2667.

Liu, X., González, G.M., Niessner, R., Haisch, C. Strong size-dependent photo­acoustic effect on gold nanoparticles: a sensitive tool for aggregation-based colorimetric protein detection, Analytical Methods (2012) 309-311. DOI: 10.1039/C1AY05497J

Haisch, C. Photoacoustic spectroscopy for analytical measurements, Measurement Science and Technology 23 (2012) 012001.

2011 and before

Helmbrecht, C., Niessner, R., Haisch, C. Photophoretic velocimetry - a new way for the in situ determination of particle size distribution and refractive index of hydrocolloids. Analyst (2011) 1987-1994.

González, G. M, Liu, X., Niessner, R., Haisch, C. Lead ion detection in turbid media by pulsed photoacoustic spectrometry based on dissolution of gold nanoparticles Sensor and Actuators B50 (2010) 770-773.

Wagner, M., Taherzadeh, D., Haisch, C., Horn, H. Investigation of the meso-scale structure and volumetric features of biofilms using Optical Coherence Tomography. Biotechnology and Bioengineering 107 (2010) 844-853.

Ivleva, N. P., Wagner, M., Horn, H., Niessner, R., Haisch, C. Raman microscopy and surface-enhanced Raman scattering (SERS) for in situ analysis of biofilms. Journal of Biophotonics 3 (2010) NA.

Knauer, M., Ivleva, P. N., Niessner, R., Haisch, C. Optimized surface-enhanced Raman scattering (SERS) colloids for the characterization of microorganisms. Analytical Sciences 26 (2010) 761-766.    Selected as Hot Article

Knauer, M., Ivleva, N. P., Liu, X., Niessner, R., Haisch, C. Surface-enhanced Raman scattering-based label-free microarray readout for the detection of microorganisms. Analytical Chemistry (2010), 82, 2766-2772.

Liu, J. X, Knauer, M., Ivleva, P. N, Niessner, R., Haisch, C. Synthesis of core-shell surface-enhanced Raman tags for bioimaging. Analytical Chemistry (2010), 82, 441-446.

Haisch, C., Opilik, L., Hays, M., Niessner, and R. Photo-thermophoresis as a new tool for aerosol characterization. Journal of Physics: Conference Series 214 (2010) 012011.

Schmid, T. Panne, U., Niessner, R., Haisch, C. Optical absorption measurements of opaque liquid samples by pulsed laser photoacoustic spectroscopy. Analytical Chemistry (2009), 81(6) 2403-2409.

Wagner, M., Ivleva, P. N, Haisch, C., Niessner, R., Horn, H. Combined use of confocal laser scanning microscopy (CLSM) and Raman microscopy (RM): Investigations on EPS – Matrix. Water Research (2009), 43(1) 63-76.

Ivleva, N. P., Wagner, M.; Horn, H.; Niessner, R.; Haisch, C. Towards a non-destructive chemical characterization of biofilm matrix by Raman microscopy. Analytical and Bioanalytical Chemistry 393 (2009) 197-206.

Ivleva, P. N, Wagner, M., Horn, H., Niessner, R., Haisch, C. In situ surface-enhanced Raman scattering analysis of biofilm. Analytical Chemistry (2008), 80(22) 8538-8544.

Haisch, C.; Kykal, C.; Niessner, R.; Photophoretic velocimetry for the characterization of Aerosols. Analytical Chemistry (2008), 80, 1546-1551.

Zell, K.; Sperl, J. I.; Vogel, M. W.; Niessner, R.; Haisch, C. Acoustical properties of selected tissue phantom materials for ultrasound imaging. Physics in Medicine and Biology (2007) 52, N475–N484.

Helmbrecht, C.; Niessner, R.; Haisch, C. Photophoretic velocimetry for colloid characterization and separation in a cross-flow setup. Analytical Chemistry (2007) 79, 7097-7103.

Haisch, C.; Niessner, R., Visualization of transient processes in biofilms by optical coherence tomography. Water Research (2007) 41, 2467-2472.

Lendl, B.; Ritter, W.; Harasek, M.; Niessner, R.; Haisch, C. Photoacoustic monitoring of CO2 in biogas matrix using a quantum cascade laser. IEEE Sensors 2006.

Radivojevic, I.; Niessner, R.; Haisch, C.; Florek, S.; Becker-Ross, H.; Panne, U. Detection of bromine in thermoplasts from consumer electronics by laser-induced plasma spectroscopy. Spectrochimica Acta, Part B: Atomic Spectroscopy (2004) 59B(3) 335-343.

Radivojevic, I.; Haisch, C.; Niessner, R.; Florek, S.; Becker-Ross, H.; Panne, U. Microanalysis by laser-induced plasma spectroscopy in the vacuum ultraviolet. Analytical Chemistry (2004) 76(6), 1648-1656.

Schmid T; Panne U; Haisch C; Niessner R. Biofilm monitoring by photoacoustic spectroscopy. Water science and technology (2003) 47(5), 25-9.

Haisch, C.; Becker-Ross, H. An electron bombardment CCD-camera as detection system for an echelle spectrometer. Spectrochimica Acta, Part B: Atomic Spectroscopy (2003) 58B(7), 1351-1357.

Schmid, T.; Helmbrecht, C.; Panne, U.; Haisch, C.; Niessner, R. Process analysis of biofilms by photoacoustic spectroscopy. Analytical and Bioanalytical Chemistry (2003) 375(8), 1124-1129.

Beck, H. A.; Niessner, R.; Haisch, C. Development and characterization of a mobile photoacoustic sensor for on-line soot emission monitoring in diesel exhaust gas. Analytical and Bioanalytical Chemistry (2003) 375(8), 1136-1143.

Schmid, T.; Helmbrecht, C.; Haisch, C.; Panne, U.; Niessner, R. On-line monitoring of opaque liquids by photoacoustic spectroscopy. Analytical and Bioanalytical Chemistry (2003) 375(8), 1130-1135.

Schmid, T.; Panne, U.; Haisch, C.; Niessner, R. Photoacoustic absorption spectra of biofilms. Review of Scientific Instruments (2003) 74(1, Pt. 2), 755-757.

Panne, U.; Neuhauser, E. R.; Haisch, C., Fink, H.; Niessner, R. Remote analysis of a mineral melt by laser-induced plasma spectroscopy. Applied Spectroscopy (2002) 56(3): 375-380.

Schmid, T.; Panne, U.; Haisch, C.; Hausner, M.; Niessner, R. A photoacoustic technique for depth-resolved in situ monitoring of biofilms. Environmental Science and Technology (2002) 36(19), 4135-4141.

Panne, U.; Neuhauser, R. E.; Haisch, C.; Fink, H.; Niessner, R. Remote analysis of a mineral melt by laser-induced plasma spectroscopy. Applied Spectroscopy (2002) 56(3), 375-380.

Florek, S.; Haisch, C.; Okruss, M.; Becker-Ross, H. A new, versatile echelle spectrometer relevant to laser induced plasma applications. Spectrochimica Acta, Part B: Atomic Spectroscopy (2001) 56B(6), 1027-1034.