Angewandte Chemie - International Edition
Abstract: The development of 18F-labelled radiotracers is of vital importance for (pre)clinical positron emission tomography (PET) imaging and to guide drug discovery campaigns. State-of-the-art approaches…
Organic Letters
Abstract: The synthesis of functionalized cubanols has been developed via a 2-step protocol comprising of a Baeyer–Villiger oxidation of cubyl ketones, followed by acid hydrolysis. As part of this study, we…
Chemical Communications
Abstract: Enantioenriched [18F]SynVesT-1 and [18F]SynVesT-2 are prepared from the corresponding enantioenriched arylboronic esters and [18F]fluoride mediated by (Py)4Cu(OTf)2. The 18F-reaction is optimised on…
Organic Letters
Abstract: 18F radiotracers are used in positron emission tomography imaging for medical diagnosis and drug development. Current methods to synthesize 18F-polyfluorinated functional groups are limited in…
Organic Letters
Abstract: (Hetero)aryl pinacol boronic esters are routinely used for 18F-labeling and have accelerated numerous diagnostic and drug discovery programs. An analysis of the current state-of-play, however,…
Journal of the American Chemical Society
Abstract: Herein, we report a photoredox nucleophilic (radio)fluorination using TEMPO-derived alkoxyamines, a class of substrates accessible in a single step from a diversity of readily available carboxylic…
Angewandte Chemie - International Edition
Abstract: Herein, we disclose that pyridinium salts derived from abundant (hetero)anilines represent a novel precursor class for nucleophilic aromatic substitution reactions with [18F]fluoride. The value of…
Organic Letters
Abstract: Herein, we report that α-fluorocarboxylic acids undergo manganese-mediated oxidative 18F-fluorodecarboxylation with [18F]-fluoride affording biologically relevant 18F-difluoromethyl(ene)-containing…
EJNMMI Radiopharmacy and Chemistry
Abstract: Background: Flumazenil (FMZ) is a functionally silent imidazobenzodiazepine which binds to the benzodiazepine binding site of approximately 75% of the brain γ-aminobutyric acid-A receptors (GABAARs).…
Nature
Abstract: The advent of total-body positron emission tomography (PET) has vastly broadened the range of research and clinical applications of this powerful molecular imaging technology1. Such possibilities have…