Technische Universität München
Lehrstuhl für Medizinische und Bioanorganische Chemie (Prof. Casini)
Lichtenbergstr. 4
85748 Garching b. München
Inorganic Medicines and Metallobiology
Metallodrugs and Catalysis in Cells
We design metal-based compounds as novel targeted therapeutic agents for the treatment of cancer or infectious diseases, since they are endowed with different modes of action with respect to organic drugs. For example, organometallic complexes of transition metals (e.g. Au, Ru, etc.) can be exploited as ‘catalysts’ of bioorthogonal transformations in cells.
Metals in Disease Mechanisms
The study of the role of metal ions (e.g. Cu, Zn, Fe) and metalloproteins in biological systems, in relation to disease mechanisms, is another active topic of our research program.
Self-assembled Metallacages As Drug Delivery Systems and Theranostic Platforms
3D-supramolecular coordination complexes featuring host-guest interactions are explored as new generation drug delivery systems and are integrated in hybrid materials for regenerative medicine applications. Self-assembly of metallacages enables the design of multimodal (nuclear) imaging and therapeutic supramolecules (see research overview).
ACS Chemical Biology
Abstract: Proteolysis targeting chimeras (PROTACs) are bifunctional molecules designed to induce the degradation of specific proteins within a cell. While most PROTACs are noncovalent interactors, covalent…
Journal of Inorganic Biochemistry
Abstract: The use of targeted chemotherapeutic agents and of locally active treatments such as photodynamic therapy (PDT), are strategies to tackle the side effects and enhance the effectiveness of anticancer…
NPJ Imaging
Abstract: The radiohybrid (rh) design of radiopharmaceuticals has recently produced new theranostics suitable for both positron emission tomography (PET) imaging and peptide receptor radionuclide therapy…
Organometallics
Abstract: The study investigates the influence of the CO group orientation on the reactivity of two geometric isomers [Ru(bipy)]m (meridional) and [Ru(bipy)]f (facial). In aprotic solvents, the strong trans…
Journal of Organometallic Chemistry
Inorganic Chemistry
Abstract: The first comprehensive study of a series of seven mesoionic tetrazolylidene gold(I) chloride complexes (1–7) featuring a range of alkyl and aryl substituents (Me, t-Bu, iPr, Ph, Tol, Dipp, Mes) is…
Journal of Inorganic Biochemistry
Abstract: The following caption for Fig. 2 is incorrect: “Representative Cy3-labeled spot map of A2780/S cells treated for 24 h with 50 μM NAMI-A. All the detected differences between the tested drug conditions…
Chemical Science
Abstract: Mass spectrometry imaging (MSI) is a versatile technique for spatially resolved multi-omics analysis in clinical research. However, its proteomic applications remain constrained by issues such as poor…
Cell Reports Physical Science
Abstract: Here, we report a general workflow for the facile microwave-assisted synthesis of kinetically inert platinum(II)-metallacages (MCgs) and their post-assembly modification (PAM) via amide coupling and…
Chemical Science
Abstract: Glioblastoma (GBM) is the most aggressive form of malignant brain cancer. Here, we synthesized two chimeric peptide-based radiopharmaceuticals (Comb-1 and Comb-2) targeted to the membrane-bound form…
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Anorganische Molekülchemie (CH4103) |
|
3 | VO | |
| Anorganische Molekülchemie, Tutorium |
|
1 | TT | |
| Anorganische Molekülchemie, Übung (CH4103) |
|
1 | UE | |
| Chemie der Wirkstoffkunde (CH0156) |
|
3 | VI | |
| Forschungspraktikum für Studierende der Biochemie (CH0943) |
|
8 | FO | |
| Forschungspraktikum mit chemischem Schwerpunkt (CH0510) |
|
8 | FO | |
| Seminar für medizinisch-anorganische Chemie |
|
1 | SE | |
| Vortragsreihe: TUM Talks Anorganisches Symposium |
|
2 | KO |