Technical University of Munich
Chair of Medicinal and Bioinorganic Chemistry (Prof. Casini)
Postal address
Postal:
Lichtenbergstr. 4
85748 Garching b. München
- Phone: +49 (89) 289 - 12212, 13831
- Homepage
- angela.casini@tum.de
Research
Inorganic Medicines and Metallobiology
Metallodrugs and Catalysis in Cells
We design metal-based compounds as novel targeted therapeutic agents for the treatment of cancer or infectious diseases, since they are endowed with different modes of action with respect to organic drugs. For example, organometallic complexes of transition metals (e.g. Au, Ru, etc.) can be exploited as ‘catalysts’ of bioorthogonal transformations in cells.
Metals in Disease Mechanisms
The study of the role of metal ions (e.g. Cu, Zn, Fe) and metalloproteins in biological systems, in relation to disease mechanisms, is another active topic of our research program.
Self-assembled Metallacages As Drug Delivery Systems and Theranostic Platforms
3D-supramolecular coordination complexes featuring host-guest interactions are explored as new generation drug delivery systems and are integrated in hybrid materials for regenerative medicine applications. Self-assembly of metallacages enables the design of multimodal (nuclear) imaging and therapeutic supramolecules.
