Technical University of Munich
Chair of Medicinal and Bioinorganic Chemistry (Prof. Casini)
Lichtenbergstr. 4
85748 Garching b. München
Inorganic Medicines and Metallobiology
Metallodrugs and Catalysis in Cells
We design metal-based compounds as novel targeted therapeutic agents for the treatment of cancer or infectious diseases, since they are endowed with different modes of action with respect to organic drugs. For example, organometallic complexes of transition metals (e.g. Au, Ru, etc.) can be exploited as ‘catalysts’ of bioorthogonal transformations in cells.
Metals in Disease Mechanisms
The study of the role of metal ions (e.g. Cu, Zn, Fe) and metalloproteins in biological systems, in relation to disease mechanisms, is another active topic of our research program.
Self-assembled Metallacages As Drug Delivery Systems and Theranostic Platforms
3D-supramolecular coordination complexes featuring host-guest interactions are explored as new generation drug delivery systems and are integrated in hybrid materials for regenerative medicine applications. Self-assembly of metallacages enables the design of multimodal (nuclear) imaging and therapeutic supramolecules (see research overview).
ACS Chemical Biology
Abstract: Proteolysis targeting chimeras (PROTACs) are bifunctional molecules designed to induce the degradation of specific proteins within a cell. While most PROTACs are noncovalent interactors, covalent…
Journal of Inorganic Biochemistry
Abstract: The use of targeted chemotherapeutic agents and of locally active treatments such as photodynamic therapy (PDT), are strategies to tackle the side effects and enhance the effectiveness of anticancer…
Journal of Inorganic Biochemistry
Abstract: The following caption for Fig. 2 is incorrect: “Representative Cy3-labeled spot map of A2780/S cells treated for 24 h with 50 μM NAMI-A. All the detected differences between the tested drug conditions…
Cell Reports Physical Science
Abstract: Here, we report a general workflow for the facile microwave-assisted synthesis of kinetically inert platinum(II)-metallacages (MCgs) and their post-assembly modification (PAM) via amide coupling and…
Journal of Organometallic Chemistry
European Journal of Nuclear Medicine and Molecular Imaging
Abstract: Abstract: The recently developed metabolically more stable minigastrin derivative, DOTA-CCK-66, displayed promising preclinical data when labeled either with 68Ga or 177Lu. First positron emission…
Biochemical Pharmacology
Abstract: Leishmaniasis is one of the most important neglected diseases, classically characterized by three clinical forms that if left untreated can lead to skin lesions, lifelong scarring, or death depending…
ChemBioChem
Abstract: The most recurrent familial cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of an abnormal number of intronic GGGGCC (G4C2) repetitions in the C9orf72…
Chem
Abstract: Metallacages (MCgs) are three-dimensional (3D)-supramolecular coordination complexes (SCCs) obtained by the self-assembly of metal ions with donor ligands, which are arranged to delimit a cavity.…
Inorganic Chemistry Frontiers
Abstract: Supramolecular self-assembly is a promising tool to develop multifunctional theranostic agents and has recently entered the field of radiochemistry. In this work, lantern-shaped [Pd2L4]4+ metallacages…
| Title | Dates | Duration | Type | Lecturer (assistant) |
|---|---|---|---|---|
| Drug Discovery Chemistry (CH0156) |
|
3 | VI | |
| Lecture Series: TUM Talks Inorganic Symposium |
|
2 | KO | |
| Medicinal Inorganic Chemistry Seminar (Prof. Casini) |
|
1 | SE | |
| Molecular Inorganic Chemistry (CH4103) |
|
3 | VO | |
| Molecular Inorganic Chemistry, Exercise (CH4103) |
|
1 | UE | |
| Molecular Inorganic Chemistry, Tutorium |
|
1 | TT | |
| Research Internship with Focus on Chemical Aspects (CH0510) |
|
8 | FO | |
| Research Laboratory Course for Biochemists (CH0943) |
|
8 | FO |