NMR Solvent Shifts and Referencing

• NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities

• NMR Chemical Shifts of Trace Impurities: Common Laboratory Solvents, Organics, and Gases in Deuterated Solvents Relevant to the Organometallic Chemist

• Development of GSK’s NMR guides – a tool to encourage the use of more sustainable solvents

• NMR Chemical Shifts of Trace Impurities: Industrially Preferred Solvents Used in Process and Green Chemistry

• TMS is Superior to Residual CHCl3 for Use as the Internal Reference for Routine 1H NMR Spectra Recorded in CDCl3

qNMR Analysis and Standards

List of qNMR Standars for quantitative NMR spectroscopy (AK Hintermann):

• AK Hintermann List of qNMR Standards 

Texts and Methods for qNMR

• Determination of standard sample purity using the high-precision 1H-NMR process

• Determining and reporting purity of organic molecules: why qNMR

• Quantitative NMR-Spektroskopie in der pharmazeutischen Analytik – Identität, Reinheit und Gehalt von Arzneistoffen

Melting Points

• Meaningful Melting Points

• "Melting Points are Uncorrected" - True or False?

• Corrected/uncorrected: Recommendation

RLi and RMgX Titration

Recommended Standard Methods AK Hintermann:

• A convenient method for estimation of alkyllithium concentrations (Diphenylacetic Acid Method for RLi)

• The Use of Salicylaldehyde Phenylhydrazone as an Indicator for the Titration of Organometallic Reagents (Preferred Method for Grignards)

Knochels general Method with Iodine/LiCl: 

• Convenient Titration Method for Organometallic Zinc, Magnesium, and Lanthanide Reagents

RLi Stability

 • Half-Lives of Organolithium Reagents in Common Ethereal Solvents

• Properties of Organolithium Reagents at Low Temperature - PharmaChem 2010, 5-6, pages 2-4