Prof. Dr. rer. nat.
Thorsten
Bach
Technical University of Munich
Chair of Organic Chemistry 1 (Prof. Bach)
Postal address
Lichtenbergstr. 4
85748 Garching b. München
New Synthetic Methods in Organic Chemistry
The major goals of our research are the development and the application of new synthetic methods in organic chemistry. The focus is on catalytic methods which enable previously unknown transformations employing both photochemical and conventional techniques. In photochemistry, we aim at the enantioselective formation of complex molecules employing catalytic approaches based on chiral sensitizers and chiral acids. Visible light has been identified as the ideal energy source to promote these and related photochemical processes. In transition metal catalysis, there is a major research interest in C(sp2)-H activation and in supramolecular approaches to the site-selective and enantioselective transformation of C(sp3)-H bonds.
With regard to total synthesis, we focus on natural products with an unusual skeleton and on molecules whose mode of action we aim to elucidate and harness in collaboration with other scientists. Examples for recently completed target compounds are shown (see research overview).
ACS Catalysis
Abstract: The design of artificial photoenzymes by incorporating synthetic chromophores into proteins represents a promising strategy to achieve non-natural biocatalytic transformations with high levels of…
Journal of the American Chemical Society
Abstract: Upon catalysis (1 mol %) by a chiral cobalt porphyrin, quinazolinones with a tethered diazo alkane precursor underwent an enantioselective C–H alkylation at carbon atom C4. Formation of five-, six-,…
Angewandte Chemie - International Edition
Abstract: Chromanes are frequently encountered as chiral structure elements in active pharmaceutical ingredients (APIs). We have now discovered an access to enantiopure chromanes, which employs a 1:1 mixture of…
Angewandte Chemie - International Edition
Abstract: A series of N,N-disubstituted buta-2,3-dienamides was prepared from 3-butynoic acid and probed as substrates in a light-induced photocyclization. It was found that xanthen-9-one (10 mol%) promotes the…
Organic Letters
Abstract: The photocycloaddition of 1,1-dimethylallene to various aromatic carbonyl compounds was found to occur exclusively at the benzene core. While the reaction with methyl 2-methoxybenzoate resulted in a…
Journal of the American Chemical Society
Abstract: By coupling a photochemical and a thermal step, a single chiral catalyst can establish a photostationary state in which the enantiopure form of a chiral compound is favored over its racemate.…
Angewandte Chemie - International Edition
Abstract: Cyclohept-2-enone-3-carboxylic acid undergoes a photochemical isomerization from its cis- to its trans-form either upon direct irradiation (λ = 366 nm) or in the presence of a triplet sensitizer…
Journal of Organic Chemistry
Abstract: 4-Substituted 7-(4′-alkenyloxy)-1-indanones were prepared from the respective substituted aryl propanoic acids and subjected to UV-A irradiation (λ = 350 or 366 nm). While the 4-chloro compound was…
Angewandte Chemie - International Edition
Abstract: Myxoquaterines represent a recently discovered class of natural products with intriguing biological properties. They were isolated from Pendulasporacea albinea MSr 11954 and display a unique structure…
Angewandte Chemie - International Edition
Abstract: Readily accessible, racemic N-carboxyanhydrides (NCAs) of α-amino acids underwent a deracemization reaction upon irradiation at λ=366 nm in the presence of a chiral benzophenone catalyst. The…
Winter term 2025/26
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Summer term 2026
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