Prof. Thorsten Bach
Prof. Dr. rer. nat.
Thorsten
Bach
Technische Universität München
Lehrstuhl für Organische Chemie (Prof. Bach)
Postadresse
Lichtenbergstr. 4
85748 Garching b. München
New Synthetic Methods in Organic Chemistry
The major goals of our research are the development and the application of new synthetic methods in organic chemistry. The focus is on catalytic methods which enable previously unknown transformations employing both photochemical and conventional techniques. In photochemistry, we aim at the enantioselective formation of complex molecules employing catalytic approaches based on chiral sensitizers and chiral acids. Visible light has been identified as the ideal energy source to promote these and related photochemical processes. In transition metal catalysis, there is a major research interest in C(sp2)-H activation and in supramolecular approaches to the site-selective and enantioselective transformation of C(sp3)-H bonds.
With regard to total synthesis, we focus on natural products with an unusual skeleton and on molecules whose mode of action we aim to elucidate and harness in collaboration with other scientists. Examples for recently completed target compounds are shown (see research overview).
Publikationen werden geladen...
ACS Catalysis
Abstract: The design of artificial photoenzymes by incorporating synthetic chromophores into proteins represents a promising strategy to achieve non-natural biocatalytic transformations with high levels of…
Journal of the American Chemical Society
Abstract: Upon catalysis (1 mol %) by a chiral cobalt porphyrin, quinazolinones with a tethered diazo alkane precursor underwent an enantioselective C–H alkylation at carbon atom C4. Formation of five-, six-,…
Angewandte Chemie - International Edition
Abstract: A series of N,N-disubstituted buta-2,3-dienamides was prepared from 3-butynoic acid and probed as substrates in a light-induced photocyclization. It was found that xanthen-9-one (10 mol%) promotes the…
Organic Letters
Abstract: We have developed a photoredox-initiated non-decarboxylative C–H fluorination of carboxylic acids. Using Selectfluor as the fluorinating agent, a range of primary and secondary carboxylic acids were…
Journal of the American Chemical Society
Abstract: The photochemical deracemization of aza-1-isoindolinones has been investigated. A chiral para-methoxy-substituted phenyl ketone was discovered that promotes the conversion of racemic…
Organic Letters
Abstract: The photocycloaddition of 1,1-dimethylallene to various aromatic carbonyl compounds was found to occur exclusively at the benzene core. While the reaction with methyl 2-methoxybenzoate resulted in a…
Angewandte Chemie - International Edition
Abstract: Chromanes are frequently encountered as chiral structure elements in active pharmaceutical ingredients (APIs). We have now discovered an access to enantiopure chromanes, which employs a 1:1 mixture of…
Journal of the American Chemical Society
Abstract: By coupling a photochemical and a thermal step, a single chiral catalyst can establish a photostationary state in which the enantiopure form of a chiral compound is favored over its racemate.…
Accounts of Chemical Research
Abstract: Millions of chiral compounds contain a stereogenic sp3-hybridized carbon center with a hydrogen atom as one of the four different substituents. The stereogenic center can be edited in an increasing…
World Journal of Urology
Abstract: Purpose: Aquablation is a novel surgical technique for the treatment of benign prostatic hyperplasia (BPH).This analysis consolidates data from five international studies—WATER, WATER II, OPEN WATER,…
Sommersemester 2026
|
Titel
|
Termine
|
Dauer
|
Art
|
Vortragende/r (Mitwirkende/r)
|
|
|
|
1 |
VO
|
|
|
|
|
3 |
VO
|
|
|
|
|
1 |
UE
|
|
|
|
|
2 |
SE
|
|
|
|
|
2 |
SE
|
|
|
|
|
2 |
SE
|
|