Technische Universität München
Lehrstuhl für Medicinal and Bioinorganic Chemistry (Prof. Casini)
Lichtenbergstr. 4
85748 Garching b. München
Inorganic Medicines and Metallobiology
Metallodrugs and Catalysis in Cells
We design metal-based compounds as novel targeted therapeutic agents for the treatment of cancer or infectious diseases, since they are endowed with different modes of action with respect to organic drugs. For example, organometallic complexes of transition metals (e.g. Au, Ru, etc.) can be exploited as ‘catalysts’ of bioorthogonal transformations in cells.
Metals in Disease Mechanisms
The study of the role of metal ions (e.g. Cu, Zn, Fe) and metalloproteins in biological systems, in relation to disease mechanisms, is another active topic of our research program.
Self-assembled Metallacages As Drug Delivery Systems and Theranostic Platforms
3D-supramolecular coordination complexes featuring host-guest interactions are explored as new generation drug delivery systems and are integrated in hybrid materials for regenerative medicine applications. Self-assembly of metallacages enables the design of multimodal (nuclear) imaging and therapeutic supramolecules (see research overview).
Journal of Inorganic Biochemistry
Abstract: The following caption for Fig. 2 is incorrect: “Representative Cy3-labeled spot map of A2780/S cells treated for 24 h with 50 μM NAMI-A. All the detected differences between the tested drug conditions…
Cell Reports Physical Science
Abstract: Here, we report a general workflow for the facile microwave-assisted synthesis of kinetically inert platinum(II)-metallacages (MCgs) and their post-assembly modification (PAM) via amide coupling and…
NPJ Imaging
Abstract: The radiohybrid (rh) design of radiopharmaceuticals has recently produced new theranostics suitable for both positron emission tomography (PET) imaging and peptide receptor radionuclide therapy…
Chemical Science
Abstract: Mass spectrometry imaging (MSI) is a versatile technique for spatially resolved multi-omics analysis in clinical research. However, its proteomic applications remain constrained by issues such as poor…
Journal of Inorganic Biochemistry
Abstract: The use of targeted chemotherapeutic agents and of locally active treatments such as photodynamic therapy (PDT), are strategies to tackle the side effects and enhance the effectiveness of anticancer…
Journal of Organometallic Chemistry
ACS Chemical Biology
Abstract: Proteolysis targeting chimeras (PROTACs) are bifunctional molecules designed to induce the degradation of specific proteins within a cell. While most PROTACs are noncovalent interactors, covalent…
Inorganic Chemistry
Abstract: The coordination capacity of thiosemicarbazone ligands and their synergism with palladium(II) ions modulate their reactivity, allowing custom design. Using thiosemicarbazones with two potential stable…
Journal of Chemical Theory and Computation
Abstract: The structural dynamics of self-assembled metallacages is important because it determines their function and stability in different applications involving encapsulation and release of a guest…
Biochemical Pharmacology
Abstract: Leishmaniasis is one of the most important neglected diseases, classically characterized by three clinical forms that if left untreated can lead to skin lesions, lifelong scarring, or death depending…
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Anorganische Molekülchemie (CH4103) |
|
3 | VO | |
| Anorganische Molekülchemie, Tutorium |
|
1 | TT | |
| Anorganische Molekülchemie, Übung (CH4103) |
|
1 | UE | |
| Chemie der Wirkstoffkunde (CH0156) |
|
3 | VI | |
| Forschungspraktikum für Studierende der Biochemie (CH0943) |
|
8 | FO | |
| Forschungspraktikum mit chemischem Schwerpunkt (CH0510) |
|
8 | FO | |
| Seminar für medizinisch-anorganische Chemie |
|
1 | SE | |
| Vortragsreihe: TUM Talks Anorganisches Symposium |
|
2 | KO |